Preventative and treatment effects of Bulema Lacera extract on chronic renal failure (CRF) in a mouse model

Khanh Linh Trinh, Van Cuong Tran

Vol. 2 Issue 1. p. 13- 17 (2020)

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ABSTRACT: In Vietnam, there are many patients with chronic renal failure (CRF). They must undergo hemodialysis periodically, peritoneal dialysis, or a kidney transplant which is very expensive. Many patients die because they cannot afford treatment. Our study aimed at finding the scientific basis for developing an affordable, available drug from Vietnamese medicinal herbs to prevent and treat CRF in an experimental model. The aerial part of Blumea lacera was collected in Sa Pa, Lao Cai and dried and minced as raw materials for extraction with different polarizing solvents to qualitatively determine its chemical composition. The B. lacera’s ethanol extract was tested for both its preventive and treatment effects on a CRF model induced by adenine in mice. The results showed that B. lacera contains major chemical components including flavonoids, alkaloids, saponin, tannins, sterols, carotenoids, polysaccharides, organic acids, and reduced sugars. Additionally, the B. lacera ethanol extract has shown to have significant preventive as well as treatment effects on chronic renal failure models induced by adenine.

KEYWORDS: Blumea lacera; ethanol extract; adenine; chronic renal failure